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in-vitro fertilization (IVF)

Journal article . Deadline 2020-03-13

Background- This is a forthcoming study of those patients, who undergo for in-vitro fertilization (IVF) and freeze-all embryo, who acquiesce for the study. To study the histopathological changes in the endometrium wall of uterus allied with the enhanced serum progesterone level during ovarian stimulation for in-vitro fertilization (IVF).

Methods: The number of participated patients (n=350) in this study, underwent for in-vitro fertilization (IVF). The blood sample was collected from patients to evaluate the level of serum progesterone in vacuum vials on the day of ovulation trigger. After the 36 hrs of ovulation trigger, ovum picked up was done. Quantitative methods were used to estimate the level of serum progesterone through the electro chemiluminescence immunoassay and Correlation of serum progesterone with embryo transfer (ET) outcomes.

Results: The main outcome of this current study was to evaluate the value of mean serum progesterone level i.e.0.868± 0.712 ng/ml and 0.88± 0.723 ng/ml was found in case of pregnancy positive and negative respectively, at p=0.216 value. In antagonist (n=40) and agonist (n=310) cases, it was 8(20%) and 37(11.94%) PL occurrence was noted at p=0.143 respectively. An overall value of the premature lutenization (PL) occurrences was 13.63% and 15.25% observed in both positive and negative cases of pregnancy at p=0.216 respectively.

Conclusion: This study concluded that the 12.66% of PL occurrences was recorded in case of IVF. The PL occurrence, neither dependent on different IVF protocols or nor affect the pregnancy rate. Study results prove that there was no significant effect of PL on pregnancy outcomes.